Bilirubin (Direct) Labkit

Sulfanilic acid | Colorimetric

Product description:

Bilirubin is derived from the haemoglobin of aged or damaged red blood cells. Bilirubin does not contain iron, but is rather a derivative of the heme group. Some part of serum bilirubin is carried in the plasma to the liver, where it is conjugated to form bilirubin diglucuronide and excreted in the bile. Conjugated bilirubin is also referred to as direct bilirubin. The remaining part of serum bilirubin is called unconjugated or indirect bilirubin. Unconjugated bilirubin is not water soluble and is transported in the plasma bound to albumin. In the liver, unconjugated bilirubin is conjugated with glucuronic acid by the enzyme uridine diphosphate-glucuronyl transferase (UDPGT) to form conjugated bilirubin which is water soluble. Conjugated bilirubin is excreted into the bile and then into the intestine. In the intestine, some of the conjugated bilirubin is converted to urobilinogen by bacterial action. A small amount of urobilinogen is reabsorbed from the intestine, enters the portal circulation and is excreted by the kidney.